"Although ivermectin is generally well tolerated at doses authorised for other indications, side effects could increase with the much higher doses that would be needed to obtain concentrations of ivermectin in the lungs that are effective against the virus. Toxicity when ivermectin is used at higher than approved doses therefore cannot be excluded."
Wouldn't it be good to investigate what side effects (reactions) have been reported in EudraVigilance for Ivermectine? This chapter gives some examples of what questions could be asked to the database. Can you come up with more questions? Is Ivermectine, a product or a substance? Is it in any of the drug lists?
select * from import.products where name ilike '%iverm%';
Ivermectine is not found.
select * from import.substances where name ilike '%iverm%';
Results in one row and a substance_id. When we check the substance table, we find
3015 unique reports for this substance.
select 'substance reports' as reported_on, count(distinct local_number) from import.substance where substance_id = 23261;
What outcomes do the reports on the Ivermectine substance have?
select outcome, count(distinct local_number) from import.substance_reaction where substance_id = 23261 group by outcome;
|Not Recovered/Not Resolved||461|
|Recovered/Resolved With Sequelae||24|
How does this compare to f.i. the outcomes for the "COVID-19 MRNA VACCINE PFIZER-BIONTECH (TOZINAMERAN)"" substance?
select outcome, count(distinct local_number) from import.substance_reaction where substance_id = 42325700 group by outcome;
|Not Recovered/Not Resolved||354461|
|Recovered/Resolved With Sequelae||27910|
We know that there are
3015 reports on the Ivermectine substance. We know there are
1034542 reports on the Tozinameran substance with the substance_id
What is the percentage of "Fatal" outcomes for each of these substances?
282 / 3015 = 0.0935.. ~ 9%
13723 / 1034542 = 1.3264.. ~ 1%
And for "Recovered/Resolved"?
1661 / 3015 = 0.5509.. ~ 55%
357564 / 1034542 = 1.3264.. ~ 34%
We have not looked at the dates of the reports and maybe we are over generalizing. But it is interesting to break this research down further. Can you think of more advanced questions you want answered in comparing substances?
Is Ivermectine mentioned in any of the drug lists? Let's find out and by joining all drug_list counts for the unique number of reports.
select 'product'as class, 'suspect' as list_type, count(distinct local_number) as count from import.product_subject_drug_list where drugs ilike '%iverm%' UNION select 'product'as class, 'concomitant' as list_type, count(distinct local_number) as count from import.product_concomitant_drug_list where drugs ilike '%iverm%' UNION select 'substance'as class, 'suspect' as list_type, count(distinct local_number) as count from import.substance_subject_drug_list where drugs ilike '%iverm%' UNION select 'substance'as class, 'concomitant' as list_type, count(distinct local_number) as count from import.substance_concomitant_drug_list where drugs ilike '%iverm%';
There are mentions in the drug lists. It would be good to relate them back to substances and products.