A recent strong increase in heavy menstrual bleeding, was mentioned in the British Medical Journal (BMJ). It is unclear if EMA has looked into this based on their data, what happens when we do it?
select reaction, count(distinct local_number) from import.product_reaction where reaction ilike '%menstru%' group by reaction order by count(distinct local_number) desc limit 10;
We can see that related to products, there are
1920 reports mentioning Heavy menstrual bleeding as (one of the) reaction(s).
|Heavy menstrual bleeding||1920|
|Menstrual cycle management||6|
select reaction, count(distinct local_number) from import.substance_reaction where reaction ilike '%menstru%' group by reaction order by count(distinct local_number) desc limit 10;
|Heavy menstrual bleeding||48794|
|Menstrual cycle management||300|
For substances it is
We want to see if any substances stick out.
select a.name, b.* from (select --reaction, substance_id, count(distinct local_number) count from import.substance_reaction where reaction = 'Heavy menstrual bleeding' group by substance_id, reaction) b JOIN import.substances a on a.substance_id = b.substance_id order by b.count desc limit 10;
|COVID-19 MRNA VACCINE PFIZER-BIONTECH (TOZINAMERAN)||42325700||25570|
|COVID-19 MRNA VACCINE MODERNA (ELASOMERAN)||40983312||7791|
|COVID-19 VACCINE ASTRAZENECA (CHADOX1 NCOV-19)||40995439||5062|
|COVID-19 MRNA VACCINE PFIZER-BIONTECH ORIGINAL/OMICRON BA.1 (TOZINAMERAN, RILTOZINAMERAN)||60123556||212|
It seems that, given that "Heavy menstrual bleeding" totals
48794 reports for the substance table and
38423 reports from that same table are related to COVID-19 vaccines, we feel that this should be something of concern. This appears to be something that justifies further research, also by EMA.