Menstrual issues

A recent strong increase in heavy menstrual bleeding, was mentioned in the British Medical Journal (BMJ). It is unclear if EMA has looked into this based on their data, what happens when we do it?

select
  reaction,
  count(distinct local_number)
from import.product_reaction 
where reaction ilike '%menstru%' 
group by reaction 
order by count(distinct local_number) desc limit 10;

We can see that related to products, there are 1920 reports mentioning Heavy menstrual bleeding as (one of the) reaction(s).

select
 reaction,
 count(distinct local_number)
from import.substance_reaction 
where reaction ilike '%menstru%' 
group by reaction 
order by count(distinct local_number) desc limit 10;

For substances it is 48794reports.

We want to see if any substances stick out.

select a.name, b.* from 
(select
   --reaction,
   substance_id,
   count(distinct local_number) count
 from import.substance_reaction 
 where reaction = 'Heavy menstrual bleeding'
 group by substance_id, reaction) b
 JOIN import.substances a on a.substance_id = b.substance_id
 order by b.count desc limit 10;

It seems that, given that "Heavy menstrual bleeding" totals 48794 reports for the substance table and 38423 reports from that same table are related to COVID-19 vaccines, we feel that this should be something of concern. This appears to be something that justifies further research, also by EMA.